COMPARISON OF CLINICAL BIOMARKER AND DNAM-DERIVED BIOLOGICAL AGE MEASURES IN AN ELECTIVE SURGERY COHORT
Daniel Parker, Shelley McDonald, Kathryn Porter Starr, Dan Blazer, III, E Shelley Hwang, Allan Kirk, Sandhya Lagoo-Deenadayalan · 2023
Read COMPARISON OF CLINICAL BIOMARKER AND DNAM-DERIVED BIOLOGICAL AGE MEASURES IN AN ELECTIVE SURGERY COHORT by Daniel Parker, Shelley McDonald, Kathryn Porter Starr, Dan Blazer, III, E Shelley Hwang, Allan Kirk, Sandhya Lagoo-Deenadayalan (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10735333.txt.
Description
Daniel Parker and co-authors compare ways of measuring biological age in 119 older adults preparing for elective surgery. Some measures come from routine clinical biomarkers, while others are read from DNA methylation patterns in blood. The team computed how far each person's biological age ran ahead of their calendar age. They then checked how the measures related to each other and to sex, race, body mass, surgery type, and surgical risk scores.
On average, the group was biologically older than its years. Male sex and African American race were linked to faster aging on most measures, and surgery type showed consistent links as well. Greater age advancement also went with higher anaesthesia risk scores. The team is now testing which measures best predict poor outcomes after surgery, with an eye to preparing high-risk patients beforehand.
Catalog record
| CREATOR | Daniel Parker, Shelley McDonald, Kathryn Porter Starr, Dan Blazer, III, E Shelley Hwang, Allan Kirk, Sandhya Lagoo-Deenadayalan |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |