Generalized Michaelis–Menten rate law with time-varying molecular concentrations
Roktaek Lim, Thomas L. P. Martin, Junghun Chae, Woo Joong Kim, Cheol-Min Ghim, Pan-Jun Kim, Pedro Mendes, Pedro Mendes, Pedro Mendes, Pedro Mendes · 2023
Read Generalized Michaelis–Menten rate law with time-varying molecular concentrations by Roktaek Lim, Thomas L. P. Martin, Junghun Chae, Woo Joong Kim, Cheol-Min Ghim, Pan-Jun Kim, Pedro Mendes, Pedro Mendes, Pedro Mendes, Pedro Mendes (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10735182.txt.
Description
Lim and co-authors published this theory paper in twenty twenty-three on a classic rule of biochemistry. The Michaelis-Menten law describes how fast enzymes drive chemical reactions in cells. For over a century, users have assumed that the bound complex of molecules settles almost at once. In living cells, molecule levels often change too fast for that assumption to hold.
The authors drop the old assumption and build a broader version of the law. Their method accounts for the time delay while molecular complexes form. It fits protein-protein and protein-DNA interactions better than the classic rule. The framework also helps explain rhythmic patterns, such as daily cycles in protein turnover and the way cells adapt to change.
Catalog record
| CREATOR | Roktaek Lim, Thomas L. P. Martin, Junghun Chae, Woo Joong Kim, Cheol-Min Ghim, Pan-Jun Kim, Pedro Mendes, Pedro Mendes, Pedro Mendes, Pedro Mendes |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |