Comparison of Transcription Elongation Rates of Three RNA Polymerases in Real Time
Priyanka Tare, Tuhin Bhowmick, Gurunath Katagi, Arnab China, Valakunja Nagaraja · 2023
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Description
Priyanka Tare and co-authors compare the working speeds of RNA polymerase enzymes from three bacteria in a 2023 paper. These enzymes copy DNA into RNA at rates that vary by species, and that pace may tune cell growth. Elongation was long treated as a steady, even process.
Using a surface sensor that watches synthesis in real time, the team fed the data into a flow model that reveals the steps of elongation. The enzymes came from two mycobacteria and from E coli, species with very different growth speeds. Each enzyme showed its own modular rate profile rather than one flat pace. The order of speeds matched the order of growth rates across the three species. The authors suggest elongation pace is a tuned trait, not a fixed constant.
Catalog record
| CREATOR | Priyanka Tare, Tuhin Bhowmick, Gurunath Katagi, Arnab China, Valakunja Nagaraja |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |