Relations between Glucose and d-Amino Acids in the Modulation of Biochemical and Functional Properties of Rodent Islets of Langerhans
Cindy · 2023
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Description
Lee and colleagues studied in 2023 how glucose and d-amino acids shape the work of rodent islets of Langerhans, the pancreatic cell clusters that manage blood sugar. Certain d-amino acids sit in insulin-making beta cells or glucagon-making alpha cells and bind receptors tied to insulin release. How glucose changes their levels was little known.
Isolated islets were exposed to low or high glucose, and levels of three d-amino acids were measured inside and outside the cells. Inner levels varied a lot and barely moved with glucose. Outer levels of two of them fell at high glucose. Adding those two also changed the calcium waves that signal insulin release, while their mirror forms did not. The work adds detail on islet signaling.
Catalog record
| CREATOR | Cindy |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |