Anatomical substrates and connectivity for bradykinesia motor features in Parkinson’s disease after subthalamic nucleus deep brain stimulation
Min Jae Kim, Yiwen Shi, Jasmine Lee, Yousef Salimpour, William S Anderson, Kelly A Mills · 2023
Read Anatomical substrates and connectivity for bradykinesia motor features in Parkinson’s disease after subthalamic nucleus deep brain stimulation by Min Jae Kim, Yiwen Shi, Jasmine Lee, Yousef Salimpour, William S Anderson, Kelly A Mills (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10733813.txt.
Description
Kim and co-authors report a study from two thousand twenty-three on where deep brain stimulation acts to ease the slowness of Parkinson's disease. Slowness, or bradykinesia, blends three faults: movements that are small, that fade with repetition, and that lose rhythm. Knowing which fault lives where in the target nucleus could guide personalized therapy.
Fifteen patients did a hand grasping task with stimulation on and off while a motion sensor tracked amplitude and frequency. Raters scored severity blind to the setting. Maps of the stimulated tissue showed amplitude and frequency changes spread as a gradient, partly overlapping, partly distinct. Bigger amplitude gains tracked better clinical scores for both hands. Connectivity maps from a standard brain atlas linked each component to its own network.
Catalog record
| CREATOR | Min Jae Kim, Yiwen Shi, Jasmine Lee, Yousef Salimpour, William S Anderson, Kelly A Mills |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |