Mechanisms behind changes of neurodegeneration biomarkers in plasma induced by sleep deprivation
Per Kristian Eide, Aslan Lashkarivand, Are Hugo Pripp, Lars Magnus Valnes, Markus Hovd, Geir Ringstad, Kaj Blennow, Henrik Zetterberg · 2023
Read Mechanisms behind changes of neurodegeneration biomarkers in plasma induced by sleep deprivation by Per Kristian Eide, Aslan Lashkarivand, Are Hugo Pripp, Lars Magnus Valnes, Markus Hovd, Geir Ringstad, Kaj Blennow, Henrik Zetterberg (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10733810.txt.
Description
Losing one night of sleep shifts the blood levels of proteins tied to brain degeneration, but the plumbing behind the shift is unclear. Eide and co-authors compared volunteers who stayed awake all night with others who slept freely. In the morning they measured five such proteins in blood. They also used a tracer injected into the spinal fluid to gauge two clearance systems: the lymphatic vessels of the brain's membranes and the glymphatic flow inside the brain.
After the sleepless night, blood levels of the two amyloid-beta forms fell, while the other markers held steady. In the sleepers, overnight amyloid changes tracked the membrane lymphatic clearance measure, not the glymphatic one. A tau marker instead tracked the glymphatic measure in the sleep-deprived group. The authors conclude that the biomarkers answer to sleep through different routes, so one mechanism cannot explain them all.
Catalog record
| CREATOR | Per Kristian Eide, Aslan Lashkarivand, Are Hugo Pripp, Lars Magnus Valnes, Markus Hovd, Geir Ringstad, Kaj Blennow, Henrik Zetterberg |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |