Neuronal deletion of phosphatase and tensin homolog in mice results in spatial dysregulation of adult hippocampal neurogenesis
Sarah E. Latchney, Brayan R. Ruiz Lopez, Paige D. Womble, Katherine J. Blandin, Joaquin N. Lugo · 2023
Read Neuronal deletion of phosphatase and tensin homolog in mice results in spatial dysregulation of adult hippocampal neurogenesis by Sarah E. Latchney, Brayan R. Ruiz Lopez, Paige D. Womble, Katherine J. Blandin, Joaquin N. Lugo (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10733516.txt.
Description
A gene that holds back cell growth also shapes where new neurons are born in the adult brain, and a 2023 mouse study by Sarah E. Latchney and co-authors maps that effect. The gene, Pten, is a tumor suppressor known to limit the copying of neural stem and progenitor cells.
The team deleted the gene in neurons and counted new-cell stages across the hippocampus, the brain's memory hub, at four and ten weeks of age. Counts covered dividing cells, young neurons, and dying cells in several subregions, plus a second birth zone near the brain's fluid spaces. Deletion brought steady rises in dividing cells and young neurons in the dentate gyrus. The pattern shows the gene also steers the layout of adult brain growth.
Catalog record
| CREATOR | Sarah E. Latchney, Brayan R. Ruiz Lopez, Paige D. Womble, Katherine J. Blandin, Joaquin N. Lugo |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |