Direct activation of airway sensory C‐fibers by SARS‐CoV‐2 S1 spike protein
Joyce S Kim, Fei Ru, Sonya Meeker, Bradley J Undem · 2023
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Description
Joyce Kim, Fei Ru, Sonya Meeker and Bradley Undem asked whether the SARS-CoV-2 spike protein can switch on airway nerves directly in 2023. They used a mouse trachea and lung preparation with calcium imaging and nerve recordings.
About half of the sensory fibres responded to the S1 spike protein, and recordings confirmed firing in the small C-fibres that drive cough and irritation. In isolated vagal neurons, 63 percent responded to S1. Direct activation of these nerve endings could help explain symptoms like sore throat and coughing. It may even speed viral spread, since sneezes and secretions carry the virus to others.
Catalog record
| CREATOR | Joyce S Kim, Fei Ru, Sonya Meeker, Bradley J Undem |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |