Low level of tonic interferon signalling is associated with enhanced susceptibility to SARS-CoV-2 variants of concern in human lung organoids
Meaghan Flagg, Kerry Goldin, Lizzette Pérez-Pérez, Manmeet Singh, Brandi N. Williamson, Nathanael Pruett, Chuong D. Hoang, Emmie de Wit · 2023
Read Low level of tonic interferon signalling is associated with enhanced susceptibility to SARS-CoV-2 variants of concern in human lung organoids by Meaghan Flagg, Kerry Goldin, Lizzette Pérez-Pérez, Manmeet Singh, Brandi N. Williamson, Nathanael Pruett, Chuong D. Hoang, Emmie de Wit (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10732190.txt.
Description
Meaghan Flagg and co-authors study COVID virus variants in human lung organoids in a 2023 paper. People vary hugely in how sick the virus makes them, and the reasons stay partly hidden. The team grew mini lung tissues from several donors and infected them with an early strain plus the Delta and Omicron variants of concern.
Omicron grew weakly in the organoids overall. Organoids from one donor, though, let both Omicron and the early strain grow much better than the others. Gene activity scans tied that openness to low baseline interferon signaling, the resting hum of antiviral defense. The authors propose that each person's resting interferon level helps set their risk from new variants, and that organoids can model that spread.
Catalog record
| CREATOR | Meaghan Flagg, Kerry Goldin, Lizzette Pérez-Pérez, Manmeet Singh, Brandi N. Williamson, Nathanael Pruett, Chuong D. Hoang, Emmie de Wit |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |