Sutterella and its metabolic pathways positively correlate with vaccine-elicited antibody responses in infant rhesus macaques
Danting Jiang, Ria Goswami, Maria Dennis, Holly Heimsath, Pamela A. Kozlowski, Amir Ardeshir, Koen K. A. Van Rompay, Kristina De Paris, Sallie R. Permar, Neeraj K. Surana · 2023
Read Sutterella and its metabolic pathways positively correlate with vaccine-elicited antibody responses in infant rhesus macaques by Danting Jiang, Ria Goswami, Maria Dennis, Holly Heimsath, Pamela A. Kozlowski, Amir Ardeshir, Koen K. A. Van Rompay, Kristina De Paris, Sallie R. Permar, Neeraj K. Surana (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10731017.txt.
Description
Jiang and co-authors (2023) looked for gut microbes that track with stronger vaccine responses in infant monkeys. The microbes living in the gut help shape immunity, but which features matter for vaccines is unclear. The team sequenced gut bacteria in 215 stool samples from 64 infant rhesus macaques. The monkeys received various HIV vaccine regimens in their first eight months. The team also measured gut chemicals the microbes make.
Age, birth year, and vaccination status all shaped the young gut community. One Sutterella species stood out: more of it went with stronger antibody responses, and five of its metabolic pathways shared the link. Several of the gut chemicals tied to those pathways also rose with antibody levels. The authors describe a two-way street, where vaccine regimens reshape the gut community and certain microbes in turn help the vaccine work, knowledge that could improve vaccines designed for early life.
Catalog record
| CREATOR | Danting Jiang, Ria Goswami, Maria Dennis, Holly Heimsath, Pamela A. Kozlowski, Amir Ardeshir, Koen K. A. Van Rompay, Kristina De Paris, Sallie R. Permar, Neeraj K. Surana |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |