Endothelial cell clonality, heterogeneity and dysfunction in pulmonary arterial hypertension
Geoffrey Newcomb, Laszlo Farkas · 2023
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Description
Geoffrey Newcomb and Laszlo Farkas review the role of vessel lining cells in pulmonary arterial hypertension in a 2023 paper. In this disease, pressure in the lung arteries rises as the vessels remodel. The lining cells keep the vessel wall sound, control gas exchange, and help set vessel tone, so their failure sits near the heart of the process.
Single cell studies show several distinct kinds of lining cells in the lung, each with its own traits. Injury or low oxygen can trigger a faulty repair response that draws in other vessel cells and immune cells. The review covers cell cloning, immune imbalance, and gene mutations as drivers, and offers a frame for the biology.
Catalog record
| CREATOR | Geoffrey Newcomb, Laszlo Farkas |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |