Brewpitopes: a pipeline to refine B-cell epitope predictions during public health emergencies
Roc Farriol-Duran, Ruben López-Aladid, Eduard Porta-Pardo, Antoni Torres, Laia Fernández-Barat · 2023
Read Brewpitopes: a pipeline to refine B-cell epitope predictions during public health emergencies by Roc Farriol-Duran, Ruben López-Aladid, Eduard Porta-Pardo, Antoni Torres, Laia Fernández-Barat (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10730938.txt.
Description
Roc Farriol-Duran and co-authors present a 2023 paper on a software pipeline called Brewpitopes. The pipeline sharpens computer predictions of B-cell epitopes, the small parts of a germ that antibodies latch onto. Finding good epitopes helps teams design vaccines and antibody drugs, but testing each one in the lab is slow and costly.
Many prediction tools exist, and each has weak points. Brewpitopes merges several of them and then applies sensible filters. The filters check where in the cell a part sits, whether sugars cover it, and whether antibodies can reach its surface. Tested on the virus that causes COVID-19, the pipeline gave a fivefold gain in predicted neutralizing sites on the spike protein. It also tracked how new variants change that landscape.
Catalog record
| CREATOR | Roc Farriol-Duran, Ruben López-Aladid, Eduard Porta-Pardo, Antoni Torres, Laia Fernández-Barat |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |