Prognostic gene HLA‐DMA associated with cell cycle and immune infiltrates in LUAD
Ya‐jie Huang, Jian‐kun He, Xiaoyang Duan, Ran Hou, Jian Shi · 2023
Read Prognostic gene HLA‐DMA associated with cell cycle and immune infiltrates in LUAD by Ya‐jie Huang, Jian‐kun He, Xiaoyang Duan, Ran Hou, Jian Shi (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10730455.txt.
Description
Ya-jie Huang and co-authors flag a gene called HLA-DMA as a marker for outlook and immune entry in lung cancer, in work from twenty twenty-three. The cancer in focus is lung adenocarcinoma, the top subtype of its class. The tissue around a tumour shapes how the cancer grows and spreads. Immune and support parts of that tissue matter for care choices. The team hunts for tissue-linked genes that track with patient outlook.
Data come from two large public cancer databases with gene and outcome records. Immune scores track with longer survival in the data. Network and survival screens single out HLA-DMA as a hub gene. Its levels run low in tumour tissue and link to key clinical traits. Higher levels track with longer survival and more immune entry. Lab tests show the gene can slow cell growth by pausing the cell cycle.
Catalog record
| CREATOR | Ya‐jie Huang, Jian‐kun He, Xiaoyang Duan, Ran Hou, Jian Shi |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |