Butyrate reduces adherent-invasive E. coli-evoked disruption of epithelial mitochondrial morphology and barrier function: involvement of free fatty acid receptor 3
Samira A Hamed, Armaan Mohan, Saranya Navaneetha Krishnan, Arthur Wang, Marija Drikic, Nicole L Prince, Ian A Lewis, Jane Shearer, Åsa V Keita, Johan D Söderholm, Timothy E Shutt, Derek M McKay · 2023
Read Butyrate reduces adherent-invasive E. coli-evoked disruption of epithelial mitochondrial morphology and barrier function: involvement of free fatty acid receptor 3 by Samira A Hamed, Armaan Mohan, Saranya Navaneetha Krishnan, Arthur Wang, Marija Drikic, Nicole L Prince, Ian A Lewis, Jane Shearer, Åsa V Keita, Johan D Söderholm, Timothy E Shutt, Derek M McKay (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10730202.txt.
Description
Samira A. Hamed and colleagues published a 2023 laboratory study on protecting the gut lining from a harmful strain of E. coli linked to Crohn's disease. The invading bacteria break up the energy-producing networks inside gut cells, which weakens the barrier between the gut and the body. The team tested whether butyrate, a fatty acid made by helpful gut microbes, could prevent that damage.
In human gut organoids and a gut cell line, butyrate reduced the bacterial damage, preserved cell energy function, and changed how the bacteria themselves used fuel. A specific fatty acid receptor on the cells played a role. The findings support gut-made chemicals as possible therapy ingredients.
Catalog record
| CREATOR | Samira A Hamed, Armaan Mohan, Saranya Navaneetha Krishnan, Arthur Wang, Marija Drikic, Nicole L Prince, Ian A Lewis, Jane Shearer, Åsa V Keita, Johan D Söderholm, Timothy E Shutt, Derek M McKay |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |