Discovery of U2AF1 neoantigens in myeloid neoplasms
Melinda Ann Biernacki, Jessica Lok, Ralph Graeme Black, Kimberly A Foster, Carrie Cummings, Kyle B Woodward, Tim Monahan, Vivian G Oehler, Derek L Stirewalt, David Wu, Anthony Rongvaux, Hans Joachim Deeg, Marie Bleakley · 2023
Read Discovery of U2AF1 neoantigens in myeloid neoplasms by Melinda Ann Biernacki, Jessica Lok, Ralph Graeme Black, Kimberly A Foster, Carrie Cummings, Kyle B Woodward, Tim Monahan, Vivian G Oehler, Derek L Stirewalt, David Wu, Anthony Rongvaux, Hans Joachim Deeg, Marie Bleakley (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10729103.txt.
Description
Melinda Ann Biernacki and twelve co-authors find new immune targets in blood cancers in a 2023 paper. The cancers are myelodysplastic syndromes and a related acute leukemia. Both stem from gene faults in blood stem cells. Faults in a gene called U2AF1 are common, early, and absent from healthy cells.
The team hunted for protein bits made only by the faulty gene. They found two such bits, called neoantigens, from one repeat fault. T cells that spot those bits were grown and their receptors copied. Armed T cells killed faulty cancer cells in lab and mouse tests. Healthy blood cells were left alone. The work is a proof of concept for precise cell therapy.
Catalog record
| CREATOR | Melinda Ann Biernacki, Jessica Lok, Ralph Graeme Black, Kimberly A Foster, Carrie Cummings, Kyle B Woodward, Tim Monahan, Vivian G Oehler, Derek L Stirewalt, David Wu, Anthony Rongvaux, Hans Joachim Deeg, Marie Bleakley |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |