Human motor neurons derived from induced pluripotent stem cells are susceptible to SARS-CoV-2 infection
Gioia Cappelletti, Claudia Colombrita, Fiona Limanaqi, Sabrina Invernizzi, Micaela Garziano, Claudia Vanetti, Claudia Moscheni, Serena Santangelo, Silvia Zecchini, Daria Trabattoni, Vincenzo Silani, Mario Clerici, Antonia Ratti, Mara Biasin · 2023
Read Human motor neurons derived from induced pluripotent stem cells are susceptible to SARS-CoV-2 infection by Gioia Cappelletti, Claudia Colombrita, Fiona Limanaqi, Sabrina Invernizzi, Micaela Garziano, Claudia Vanetti, Claudia Moscheni, Serena Santangelo, Silvia Zecchini, Daria Trabattoni, Vincenzo Silani, Mario Clerici, Antonia Ratti, Mara Biasin (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10728732.txt.
Description
Gioia Cappelletti and co-authors asked whether the virus behind COVID-19 can infect the motor neurons that drive muscles. Many patients report nerve and muscle symptoms during and after infection, yet these specific cells had not been tested. The team grew motor neurons from human stem cells in the lab and exposed them to the virus.
The cells carried all the known entry receptors for the virus, two of them in large amounts. The virus infected the neurons and multiplied without visibly killing them, and fluid from the infected cells could infect fresh test cells. Infection also switched many genes tied to cell survival, defense, and inflammation. The authors say this may help explain the neuromuscular problems seen in COVID-19 and long COVID.
Catalog record
| CREATOR | Gioia Cappelletti, Claudia Colombrita, Fiona Limanaqi, Sabrina Invernizzi, Micaela Garziano, Claudia Vanetti, Claudia Moscheni, Serena Santangelo, Silvia Zecchini, Daria Trabattoni, Vincenzo Silani, Mario Clerici, Antonia Ratti, Mara Biasin |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |