The prognostic value of Forkhead box P3 regulatory T cells in biliary tract cancer: A systematic review and meta-analysis
Pengcheng Cai, Zhongli Wu, Xingjian Yang, Na Wang, Yong Yang · 2023
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Description
Pengcheng Cai and four co-authors pool the evidence on whether immune cells inside bile duct cancers predict how long patients survive, in this 2023 review. The cells in question are regulatory T cells marked by the FoxP3 protein. Their day job is calming immune responses, which is healthy in most tissue and dangerous inside a tumor, where calm protects the cancer.
Searching four databases, the team found ten studies of biliary tract cancer. Patients whose tumors were heavily infiltrated by these cells died sooner overall, with a hazard ratio of 1.34. Splitting by cancer type sharpened the picture: the link was strong and clear in gallbladder cancer, but not significant in bile duct cancer proper. If the pattern holds, counting these cells in a biopsy could help forecast a patient's course and, one day, select patients for immune therapies designed to disarm the tumor's guards.
Catalog record
| CREATOR | Pengcheng Cai, Zhongli Wu, Xingjian Yang, Na Wang, Yong Yang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |