Exploring the pharmacological and molecular mechanisms of Salvia chinensis Benth in colorectal cancer: A network pharmacology and molecular docking study
Qian Zheng, Xin Wang, Tian Gao, Bingzhou Zhang, Ning Zhao, Runsen Du, Zengren Zhao · 2023
Read Exploring the pharmacological and molecular mechanisms of Salvia chinensis Benth in colorectal cancer: A network pharmacology and molecular docking study by Qian Zheng, Xin Wang, Tian Gao, Bingzhou Zhang, Ning Zhao, Runsen Du, Zengren Zhao (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10727650.txt.
Description
Qian Zheng and six co-authors probe a Chinese herb against colon cancer in a 2023 paper. The herb, Salvia chinensis Benth, aids standard therapy in traditional practice. How it acts on colorectal cancer was unknown. The team combined cell tests with computer network analysis.
The herb extract slowed two colon cancer cell lines in dishes. Databases yielded eleven active components and hundreds of targets. Matching those against cancer gene data isolated the shared targets. A protein network then highlighted the core players. Enrichment analysis pointed to the pathways involved. Docking simulations checked that key compounds fit their targets. Western blots confirmed effects on a crucial signaling pathway. The study sketches a multi target mechanism for the herb.
Catalog record
| CREATOR | Qian Zheng, Xin Wang, Tian Gao, Bingzhou Zhang, Ning Zhao, Runsen Du, Zengren Zhao |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |