Does the VHL polymorphisms rs779805 and rs1642742 affect renal cell carcinoma susceptibility, prognosis and survival in Central European population?
Magdalena Chrabańska, Nikola Szweda-Gandor, Bogna Drozdzowska · 2023
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Description
Magdalena Chrabańska and co-authors genotype two variants in the VHL tumor suppressor gene in Central European kidney cancer patients. VHL failure is the founding event of clear cell renal carcinoma, so inherited variation in the gene might shade who gets the disease and how it behaves. One hundred seventy-one cases had both variants read from tumor DNA.
Neither variant changed overall cancer risk or survival. But both carried prognostic information. One variant's G allele and its carrying genotypes tracked with larger tumors and higher nuclear grade, and with higher pathological stage; the second variant tracked with lower stage. The authors argue the pair can serve as cheap prognostic indicators alongside the classic factors clinics already use.
Catalog record
| CREATOR | Magdalena Chrabańska, Nikola Szweda-Gandor, Bogna Drozdzowska |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |