Integrated Network Pharmacology and Experimental Approach to Investigate the Protective Effect of Jin Gu Lian Capsule on Rheumatoid Arthritis by Inhibiting Inflammation via IL-17/NF-κB Pathway
Tengfei Chen, Sihan Li, Dongyin Lian, Qin Hu, Hongping Hou, Delian Niu, Han Li, Ling Song, Yunhang Gao, Ying Chen, Xiaoru Hu, Jianrong Li, Zuguang Ye, Bo Peng, Guangping Zhang · 2023
Read Integrated Network Pharmacology and Experimental Approach to Investigate the Protective Effect of Jin Gu Lian Capsule on Rheumatoid Arthritis by Inhibiting Inflammation via IL-17/NF-κB Pathway by Tengfei Chen, Sihan Li, Dongyin Lian, Qin Hu, Hongping Hou, Delian Niu, Han Li, Ling Song, Yunhang Gao, Ying Chen, Xiaoru Hu, Jianrong Li, Zuguang Ye, Bo Peng, Guangping Zhang (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10725692.txt.
Description
Tengfei Chen and colleagues published a pharmacology study in 2023 on a traditional capsule for rheumatoid arthritis. The capsule, called Jin Gu Lian, is used against joint inflammation. Its many ingredients make its action hard to trace. The team combined computer network analysis with live experiments.
Network methods listed dozens of possible targets in the body. Sixteen ingredients stood out as the likely core actives. Docking simulations checked how those compounds might bind their targets. Animal experiments then tested the predictions directly. The results pointed to one inflammatory pathway being blocked. That pathway involves signals known to drive joint damage. The layered approach links a complex herbal formula to testable mechanisms.
Catalog record
| CREATOR | Tengfei Chen, Sihan Li, Dongyin Lian, Qin Hu, Hongping Hou, Delian Niu, Han Li, Ling Song, Yunhang Gao, Ying Chen, Xiaoru Hu, Jianrong Li, Zuguang Ye, Bo Peng, Guangping Zhang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |