Interactions of Histone Deacetylase 6 with DNA Damage Repair Factors Strengthen its Utility as a Combination Drug Target in High-Grade Serous Ovarian Cancer
Jolene · 2023
Read Interactions of Histone Deacetylase 6 with DNA Damage Repair Factors Strengthen its Utility as a Combination Drug Target in High-Grade Serous Ovarian Cancer by Jolene (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10723650.txt.
Description
Two researchers map partners of the enzyme HDAC6 in aggressive ovarian cancer in a 2023 paper. High grade serous ovarian cancer is the deadliest gynecologic cancer, and most patients relapse into drug resistance. Enzyme blockers look promising, yet how HDAC6 acts in this cancer is poorly mapped.
Using substrate trapping with mass spectrometry, the team listed proteins that bind each catalytic domain of the enzyme. The first domain mutant held the most unique partners, suggesting it works independently of the second. DNA damage repair proteins, including PARP family members, appeared among the partners. The authors argue the map supports pairing HDAC blockers with platinum drugs and PARP inhibitors in this cancer.
Catalog record
| CREATOR | Jolene |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |