Neonatal Cystitis Makes Adult Female Rat Urinary Bladders More Sensitive to Low Concentration Microbial Antigens
Ashley C Archer, Jennifer J DeBerry, Cary DeWitte, Timothy J Ness · 2023
Read Neonatal Cystitis Makes Adult Female Rat Urinary Bladders More Sensitive to Low Concentration Microbial Antigens by Ashley C Archer, Jennifer J DeBerry, Cary DeWitte, Timothy J Ness (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10723592.txt.
Description
Ashley C Archer, Jennifer J DeBerry, Cary DeWitte, and Timothy J Ness published a rat study in 2023 on how a baby bladder infection can echo into adult pain. A chronic bladder pain syndrome in people flares after urinary infections, and the authors suspected early-life inflammation primes the bladder to overreact later. They inflamed newborn rats' bladders for three days with a yeast product.
As adults, those rats carried more microbial-sensor proteins in bladder and spinal cord. When bacterial or yeast mimics were placed in the adult bladder, the early-inflamed rats showed strong, dose-dependent pain responses to bladder stretching at nearly every dose. Control rats barely reacted. Early bladder insults, the study suggests, can wire the organ for lifelong oversensitivity to microbes.
Catalog record
| CREATOR | Ashley C Archer, Jennifer J DeBerry, Cary DeWitte, Timothy J Ness |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |