Arginine Biosynthesis Pathway Found to Play a Key Role in the Neuroprotective Effect of Liu-Wei-Luo-Bi (LWLB) Granules in Diabetic db/db Mice with Peripheral Neuropathy Using an Untargeted Metabolomics Strategy
Qiong Liu, Yafei Chen, Bo Wang, Yinying Chen, Bing Li, Shuang Guan, Kehe Du, Xiaoyang Liu, Yanan Yu, Jun Liu, Zhong Wang · 2023
Read Arginine Biosynthesis Pathway Found to Play a Key Role in the Neuroprotective Effect of Liu-Wei-Luo-Bi (LWLB) Granules in Diabetic db/db Mice with Peripheral Neuropathy Using an Untargeted Metabolomics Strategy by Qiong Liu, Yafei Chen, Bo Wang, Yinying Chen, Bing Li, Shuang Guan, Kehe Du, Xiaoyang Liu, Yanan Yu, Jun Liu, Zhong Wang (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10723181.txt.
Description
Qiong Liu and co-authors published a research paper in 2023 on a Chinese herbal granule formula and how it eases nerve damage in diabetic mice. The formula is prescribed for the pain and numbness that diabetes brings to the limbs. The team gave it to diabetic mice for twelve weeks at three doses, alongside standard comparators.
Treated mice conducted nerve signals faster and flinched less to touch than untreated diabetics. Blood profiling with an untargeted chemistry scan found forty-three shifted compounds. One building-block pathway, arginine production, stood out as the likely route of the benefit. The study pairs classic symptom measures with modern chemistry to explain a traditional remedy.
Catalog record
| CREATOR | Qiong Liu, Yafei Chen, Bo Wang, Yinying Chen, Bing Li, Shuang Guan, Kehe Du, Xiaoyang Liu, Yanan Yu, Jun Liu, Zhong Wang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |