Commentary: Tissue factor as a potential coagulative/vascular marker in relapsing-remitting multiple sclerosis
Nigel Mackman, Ana T.A. Sachetto · 2023
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Description
Nigel Mackman and Ana Sachetto comment on a proposed blood marker in multiple sclerosis in a 2023 piece. The study under review found lower plasma tissue factor in relapsing patients than in remitting ones or healthy controls. Its authors cast the clotting protein as a marker and possible drug target.
The commentators raise a measurement worry. The assay kit used may not read tissue factor in human plasma accurately. They cite a large cancer clot trial that used the same kit and their own tests of four commercial kits. The exchange shows how a bold biomarker claim can hinge on one assay. Readers get a cautionary tour of validation.
Catalog record
| CREATOR | Nigel Mackman, Ana T.A. Sachetto |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 5 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |