GABA has a presynaptic inhibitory effect at Lumbricus terrestris body wall muscle synapses.
William L. Coleman, Leah E. McCartney · 2023
Read GABA has a presynaptic inhibitory effect at Lumbricus terrestris body wall muscle synapses. by William L. Coleman, Leah E. McCartney (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10722302.txt.
Description
William Coleman and Leah McCartney study nerve signals in earthworm muscle, in a 2023 paper. The worm's body wall muscle gets both go and stop inputs, which makes it a handy model for nerve work. Past work looked at stop signals acting after the nerve ending. The pair asked whether the chemical GABA also acts before the ending, to cut the signal at its source.
They loaded a glowing dye into the small packets that nerves use to send signals. With GABA present, the glow at the muscle junctions dropped by a clear amount. That drop means fewer packets were primed for release. The authors read the result as proof that GABA can brake the signal at the sending side as well. The finding adds a detail to how simple nerve circuits balance go and stop cues.
Catalog record
| CREATOR | William L. Coleman, Leah E. McCartney |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 10 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |