Immune activation of the p75 neurotrophin receptor: implications in neuroinflammation
Victor Danelon, Sarah C. Garret-Thomson, Steven C. Almo, Francis S. Lee, Barbara L. Hempstead · 2023
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Description
Victor Danelon and colleagues reviewed a nerve receptor with immune ties in 2023. The receptor belongs to a large immune receptor family. Yet it acts mostly in the nervous system, not immune cells. Its shape resembles its cousins, but its habits differ. It pairs with helper receptors to do its work. It also binds loose paired signals, unlike most cousins. The review compares these traits across the family. A recent finding gives the receptor a direct immune doorway.
An immune surface protein changed during primate evolution. In humans and other primates, it can now bind this nerve receptor. In lower mammals, it cannot. That binding lets immune signals reach nerve cells directly. It can trigger removal of synapses in the brain. The authors link this route to inflammation and injury responses. They argue the receptor truly shares immune family behavior. The review reframes a nerve protein as a brain-immune bridge.
Catalog record
| CREATOR | Victor Danelon, Sarah C. Garret-Thomson, Steven C. Almo, Francis S. Lee, Barbara L. Hempstead |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |