The development of cancers research based on mitochondrial heat shock protein 90
Yuchu Xiang, Xudong Liu, Qi Sun, Kuo Liao, Xiaohan Liu, Zihui Zhao, Lishuang Feng, Yan Liu, Bo Wang · 2023
Read The development of cancers research based on mitochondrial heat shock protein 90 by Yuchu Xiang, Xudong Liu, Qi Sun, Kuo Liao, Xiaohan Liu, Zihui Zhao, Lishuang Feng, Yan Liu, Bo Wang (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10720920.txt.
Description
Yuchu Xiang and co-authors review research on a mitochondrial chaperone as a cancer target in a 2023 paper. The protein, mtHsp90, steadies many client proteins inside mitochondria and is abundant in tumors. Blocking it destabilizes those clients and disrupts several tumor pathways at once.
The review covers the protein's structure and function, then the inhibitor pipeline. One specific blocker, gamitrinib, has passed preclinical safety and efficacy work and is in clinical trials. Starving cancer's power-plant management is an elegant strategy; this paper maps how far the idea has traveled toward the clinic.
Catalog record
| CREATOR | Yuchu Xiang, Xudong Liu, Qi Sun, Kuo Liao, Xiaohan Liu, Zihui Zhao, Lishuang Feng, Yan Liu, Bo Wang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |