Mesenchymal stem cells overexpressing interleukin-10 prevent allergic airway inflammation
Peng-Peng Kuang, Xiao-Qing Liu, Chan-Gu Li, Bi-Xin He, Ying-Chun Xie, Zi-Cong Wu, Cheng-Lin Li, Xiao-Hui Deng, Qing-Ling Fu · 2023
Read Mesenchymal stem cells overexpressing interleukin-10 prevent allergic airway inflammation by Peng-Peng Kuang, Xiao-Qing Liu, Chan-Gu Li, Bi-Xin He, Ying-Chun Xie, Zi-Cong Wu, Cheng-Lin Li, Xiao-Hui Deng, Qing-Ling Fu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10720159.txt.
Description
Kuang and co-authors test in 2023 stem cells boosted to make a calming signal protein as a treatment for allergic airway disease. Both stem cells and the protein calm immune responses, so pairing them may help more. Stem cells from reprogrammed cells were engineered with a virus to overproduce the protein.
The boosted cells cut inflammatory cell entry and mucus cell growth in the lungs of allergic mice. Tests on immune cells from patients with allergic rhinitis showed shifts in helper cell types and signals. Gene reads probed how the cells act on those immune cells. The work supports cell therapy tuned by one added protective protein.
Catalog record
| CREATOR | Peng-Peng Kuang, Xiao-Qing Liu, Chan-Gu Li, Bi-Xin He, Ying-Chun Xie, Zi-Cong Wu, Cheng-Lin Li, Xiao-Hui Deng, Qing-Ling Fu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |