Vascular endothelial growth factor induces the migration of human airway smooth muscle cells by activating the RhoA/ROCK pathway
Chengtian Lv, Yuwen Huang, Ruirong Yan, Yuanmei Gao · 2023
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Description
Chengtian Lv, Yuwen Huang, Ruirong Yan, and Yuanmei Gao examine how a growth factor moves airway muscle cells, in a study published in two thousand twenty-three. In asthma, airway smooth muscle grows and migrates, thickening airway walls and worsening lung function. Vascular endothelial growth factor, VEGF, is already implicated in asthma's progression.
Earlier work emphasized VEGF's effect on muscle cell proliferation. This study isolates migration instead. Wound healing and Transwell assays measured how the cells move under VEGF's influence. The signaling ran through the RhoA and ROCK pathway, a known controller of cell movement. Blocking that pathway offers a candidate strategy against airway remodeling. The authors present their mechanistic evidence as groundwork for such treatments.
Catalog record
| CREATOR | Chengtian Lv, Yuwen Huang, Ruirong Yan, Yuanmei Gao |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |