Archaic Introgression Shaped Human Circadian Traits
Keila Velazquez-Arcelay, Laura L Colbran, Evonne McArthur, Colin M Brand, David C Rinker, Justin K Siemann, Douglas G McMahon, John A Capra · 2023
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Description
Keila Velazquez-Arcelay and seven co-authors show that DNA inherited from Neanderthals and Denisovans helped shape whether modern people are morning or evening types. Their paper appeared in two thousand twenty-three. When modern humans left Africa, they bred with these archaic cousins. The borrowed genes may have sped adaptation to new latitudes and seasons.
The team compared body-clock genes across archaic and modern genomes. Dozens of clock genes carried variants that could change splicing or regulation. Borrowed variants clustered among the switches that tune clock gene activity. Many of those variants link to chronotype in living people. The strongest borrowed effects push toward morningness. That fits the pattern seen in other species at high latitudes. Archaic legacy, it seems, still sets some of our alarms.
Catalog record
| CREATOR | Keila Velazquez-Arcelay, Laura L Colbran, Evonne McArthur, Colin M Brand, David C Rinker, Justin K Siemann, Douglas G McMahon, John A Capra |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |