Identification of candidate DNA methylation biomarkers related to Alzheimer’s disease risk by integrating genome and blood methylome data
Yanfa Sun, Jingjing Zhu, Yaohua Yang, Zichen Zhang, Hua Zhong, Guanghua Zeng, Dan Zhou, Richard S Nowakowski, Jirong Long, Chong Wu, Lang Wu · 2023
Read Identification of candidate DNA methylation biomarkers related to Alzheimer’s disease risk by integrating genome and blood methylome data by Yanfa Sun, Jingjing Zhu, Yaohua Yang, Zichen Zhang, Hua Zhong, Guanghua Zeng, Dan Zhou, Richard S Nowakowski, Jirong Long, Chong Wu, Lang Wu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10719322.txt.
Description
Yanfa Sun and co-authors hunt blood markers tied to Alzheimer's disease risk in chemical tags on DNA, in work from 2023. These tags, called methylation marks, can be gauged in blood and may flag disease paths early. The team joined gene data with blood tag data at a large scale.
Using prediction models for tag levels, they tested links to disease risk in over one hundred thousand cases and far more controls. Over a thousand tag sites linked to risk. Some sites also tied to activity of nearby genes, and thirty-two genes showed a consistent chain from tag to gene to risk. Nine of those genes were new to this disease. The work points to blood tests and drug leads.
Catalog record
| CREATOR | Yanfa Sun, Jingjing Zhu, Yaohua Yang, Zichen Zhang, Hua Zhong, Guanghua Zeng, Dan Zhou, Richard S Nowakowski, Jirong Long, Chong Wu, Lang Wu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |