Remarkable effects of infliximab on severe radiation-induced side effects in a patient with uterine cervical cancer: a case report
Amelie Toft Morén, Cecilia Bull, Karin Bergmark · 2023
Read Remarkable effects of infliximab on severe radiation-induced side effects in a patient with uterine cervical cancer: a case report by Amelie Toft Morén, Cecilia Bull, Karin Bergmark (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10718054.txt.
Description
Amelie Toft Morén, Cecilia Bull, and Karin Bergmark present a 2023 case report on an unexpected rescue for radiation-damaged bowels. Pelvic radiotherapy cures many cancers but can leave the gut chronically inflamed and dysfunctional, with few good treatments. Their patient, a woman treated for cervical cancer, suffered severe late bowel effects.
The team tried infliximab, an antibody drug that blocks a master inflammation signal and is best known for bowel disease. On a modest dose every four to six weeks, her bowel health improved remarkably, and her late-toxicity grade fell from grade two to grade zero, essentially normal. The authors urge caution, since the drug suppresses immunity, but suggest it deserves study for chronic radiation injury.
Catalog record
| CREATOR | Amelie Toft Morén, Cecilia Bull, Karin Bergmark |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |