The role of IBV PL1pro in virus replication and suppression of host innate immune responses
Weirong Liu, Ge Mu, Yiquan Jia, Mengting Yu, Songbai Zhang, Zhen Wang, Shouguo Fang · 2023
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Description
Weirong Liu and six co-authors studied a leftover piece of a virus protein and found it still does real work, in this 2023 paper. The virus causes infectious bronchitis in chickens. One of its proteins, PL1pro, was thought to be a broken remnant with no cutting power of its own, so its role was unclear.
The team built versions of the virus with that piece removed and watched them grow. The altered viruses copied themselves far more slowly. Without the piece, the virus also resisted interferon less well, and host cells raised stronger alarm signals. Adding the piece back in other tests calmed those alarms. The authors say the remnant helps the virus both multiply and hide, making it a possible drug target.
Catalog record
| CREATOR | Weirong Liu, Ge Mu, Yiquan Jia, Mengting Yu, Songbai Zhang, Zhen Wang, Shouguo Fang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |