Prognostic value of circulating tumor cells associated with white blood cells in solid cancer: a systematic review and meta-analysis of 1471 patients with solid tumors
Mingguang Ju, Ziming Gao, Gaoxiang Gu, Haibo Huang, Anqi Sun, Chen Zheng, He Li, Yixiao Zhang, Kai Li · 2023
Read Prognostic value of circulating tumor cells associated with white blood cells in solid cancer: a systematic review and meta-analysis of 1471 patients with solid tumors by Mingguang Ju, Ziming Gao, Gaoxiang Gu, Haibo Huang, Anqi Sun, Chen Zheng, He Li, Yixiao Zhang, Kai Li (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10717563.txt.
Description
Mingguang Ju and co-authors pooled the evidence on whether tumor cells traveling with white blood cells predict a cancer patient's fate. Tumors shed cells into the blood, and some ride in clusters with immune cells. Whether those clusters forecast survival has been debated. The team searched three databases through late 2022 and gathered ten studies covering 1,471 patients with solid tumors.
Patients whose blood held these clusters died sooner and saw their disease return or spread sooner than patients without them. The risk of death ran about two and a half times higher. The pattern held across subgroups sorted by sampling time, treatment, detection method, and cancer type. Clusters also tracked with larger tumors. The authors conclude the clusters are a warning sign worth measuring, though the studies behind the pool varied in their methods.
Catalog record
| CREATOR | Mingguang Ju, Ziming Gao, Gaoxiang Gu, Haibo Huang, Anqi Sun, Chen Zheng, He Li, Yixiao Zhang, Kai Li |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |