Suramin, an antiparasitic drug, stimulates adipocyte differentiation and promotes adipogenesis
Hanxiao Li, Yingyue Dong, Chunmiao Han, Lisha Xia, Yue Zhang, Tongsheng Chen, Huamin Wang, Guoheng Xu · 2023
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Description
Hanxiao Li and seven co-authors wrote this 2023 study on an old parasite drug that, oddly, grows fat. Mast cell products were already known to nudge young fat cells to mature. The drug, suramin, is a charged polymer much like one of those products, and it has treated sleeping sickness for a century. The team tested it on rat fat cells and in living rats.
Suramin pushed young fat cells to mature in dose and time steps, raising the key fat-making factors as it went. Injected into rats, it slightly boosted fat growth in several depots. Kin drugs with more charge groups acted alike, pointing to the charge groups as the drivers. The authors frame the drug as a tool for probing how fat forms.
Catalog record
| CREATOR | Hanxiao Li, Yingyue Dong, Chunmiao Han, Lisha Xia, Yue Zhang, Tongsheng Chen, Huamin Wang, Guoheng Xu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |