A positive feedback circuit driven by m6A-modified circular RNA facilitates colorectal cancer liver metastasis
Kaixuan Zeng, Jianhong Peng, Yue Xing, Linjie Zhang, Peishan Zeng, Weihao Li, Weili Zhang, Zhizhong Pan, Chi Zhou, Junzhong Lin · 2023
Read A positive feedback circuit driven by m6A-modified circular RNA facilitates colorectal cancer liver metastasis by Kaixuan Zeng, Jianhong Peng, Yue Xing, Linjie Zhang, Peishan Zeng, Weihao Li, Weili Zhang, Zhizhong Pan, Chi Zhou, Junzhong Lin (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10717141.txt.
Description
Kaixuan Zeng and co-authors traced a feedback loop that helps bowel cancer spread to the liver in 2023. Liver spread is the top cause of death in colorectal cancer. Circular RNAs, ring-shaped RNA molecules, are known players in cancer growth, but their role in this spread was little known.
One circular RNA was much higher in cancers that had spread to the liver, and high levels meant a worse outlook. It pushed cancer cells to move and invade in the lab and drove liver spread in mouse models built from patient tumors. The ring makes a short protein that blocks a brake on a growth switch, which turns on spread genes. A chemical tag on the ring boosts that protein's making.
Catalog record
| CREATOR | Kaixuan Zeng, Jianhong Peng, Yue Xing, Linjie Zhang, Peishan Zeng, Weihao Li, Weili Zhang, Zhizhong Pan, Chi Zhou, Junzhong Lin |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |