The effects of doxorubicin loaded aptamer S3-linked DNA tetrahedrons on nasopharyngeal carcinoma
Xiwu Liu, Bincan Jiang, Ailan Cheng, Youwei Guo, Lei Wang, Weidong Liu, Wen Yin, Yihan Li, Xingjun Jiang, Caiping Ren · 2023
Read The effects of doxorubicin loaded aptamer S3-linked DNA tetrahedrons on nasopharyngeal carcinoma by Xiwu Liu, Bincan Jiang, Ailan Cheng, Youwei Guo, Lei Wang, Weidong Liu, Wen Yin, Yihan Li, Xingjun Jiang, Caiping Ren (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10717102.txt.
Description
Xiwu Liu and co-authors built a aimed drug carrier in 2023 for a throat cancer that grows behind the nose. The carrier is a tiny DNA cage, a tetrahedron, tied to a short DNA strand that homes to a mark on the cancer cells. A classic cancer drug rides inside the cage. The team tested the loaded cage on cancer cells in dishes and on tumors grown in mice.
The cage homed to the cancer cells and to tumor tissue, and it spared other cells much of the drug's harm. Loaded at the best mix, it freed its drug over two days. In mice it found the grafted tumors, slowed their growth, and left healthy tissue near whole. The team calls it a safe, aimed route for this cancer.
Catalog record
| CREATOR | Xiwu Liu, Bincan Jiang, Ailan Cheng, Youwei Guo, Lei Wang, Weidong Liu, Wen Yin, Yihan Li, Xingjun Jiang, Caiping Ren |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |