Peripheral signaling pathways contributing to non-histaminergic itch in humans
Andrea Fiebig, Victoria Leibl, David Oostendorf, Saskia Lukaschek, Jens Frömbgen, Maral Masoudi, Andreas E Kremer, Marion Strupf, Peter Reeh, Miriam Düll, Barbara Namer · 2023
Read Peripheral signaling pathways contributing to non-histaminergic itch in humans by Andrea Fiebig, Victoria Leibl, David Oostendorf, Saskia Lukaschek, Jens Frömbgen, Maral Masoudi, Andreas E Kremer, Marion Strupf, Peter Reeh, Miriam Düll, Barbara Namer (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10717026.txt.
Description
Andrea Fiebig, Victoria Leibl, David Oostendorf, and eight colleagues probe itch that histamine does not explain in this two thousand twenty-three human study. Chronic itch is an unsolved treatment problem, and how outer nerves tell such itch from pain was unclear. Healthy volunteers received three itch-causing substances, beta-alanine, BAM 8-22, and cowhage extract, while the team paired felt ratings with microneurography, recordings from single nerve fibers.
How a substance was applied changed the itch-to-pain balance for two of the three agents. A prostaglandin pre-injection boosted the pain part for one agent only. Two channel proteins, TRPV1 and TRPA1, proved needed for itch from all three. Single-fiber recordings showed firing patterns for each substance, with different slow bursting patterns. The authors conclude there is no single labeled line for itch in humans; each agent uses its own mix of paths.
Catalog record
| CREATOR | Andrea Fiebig, Victoria Leibl, David Oostendorf, Saskia Lukaschek, Jens Frömbgen, Maral Masoudi, Andreas E Kremer, Marion Strupf, Peter Reeh, Miriam Düll, Barbara Namer |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |