Targeting the myeloid microenvironment in neuroblastoma
Marjolein C. Stip, Loes Teeuwen, Miranda P. Dierselhuis, Jeanette H. W. Leusen, Daniëlle Krijgsman · 2023
Read Targeting the myeloid microenvironment in neuroblastoma by Marjolein C. Stip, Loes Teeuwen, Miranda P. Dierselhuis, Jeanette H. W. Leusen, Daniëlle Krijgsman (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10716967.txt.
Description
Marjolein Stip and co-authors wrote this 2023 review on turning the tumor's own guards into attackers in neuroblastoma. This childhood cancer surrounds itself with myeloid cells, white blood cells that build a suppressive web shielding the tumor. High-risk cases lean on that shield hard.
The review first maps what each myeloid type does for and against the tumor. It then sorts the counter-strategies into three plays: recruit the cells as effectors, as already happens with anti-GD2 therapy; block their arrival or remove them; or reprogram them from guards into attackers. A warning threads the survey: draining the swamp also drains potential effectors. The most promising routes sharpen existing antibodies, for instance by blocking the don't-eat-me signal. The authors chart a crowded but hopeful front.
Catalog record
| CREATOR | Marjolein C. Stip, Loes Teeuwen, Miranda P. Dierselhuis, Jeanette H. W. Leusen, Daniëlle Krijgsman |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |