A cell‐penetrating peptide exerts therapeutic effects against ischemic stroke by mediating the lysosomal degradation of sirtuin 5
Qian Xia, Xue Zhang, Gaofeng Zhan, Lu Zheng, Meng Mao, Yin Zhao, Yilin Zhao, Xing Li · 2023
Read A cell‐penetrating peptide exerts therapeutic effects against ischemic stroke by mediating the lysosomal degradation of sirtuin 5 by Qian Xia, Xue Zhang, Gaofeng Zhan, Lu Zheng, Meng Mao, Yin Zhao, Yilin Zhao, Xing Li (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10716672.txt.
Description
Qian Xia and seven co-authors test a possible new treatment for ischemic stroke in a 2023 study. Stroke care still lacks strong drug options. Earlier work showed that a protein called SIRT5 makes brain inflammation worse after a stroke, by acting on immune cells in the brain called microglia.
The team built a small peptide that can cross cell walls and target that protein for destruction in the cell's waste system. In lab tests, the peptide calmed inflammation in microglia. In mice with stroke, it crossed into the brain, shrank the damaged area, and improved long term function. High doses caused no harm in healthy mice, which supports further study of the approach.
Catalog record
| CREATOR | Qian Xia, Xue Zhang, Gaofeng Zhan, Lu Zheng, Meng Mao, Yin Zhao, Yilin Zhao, Xing Li |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |