Metabolic brain imaging with glucosamine CEST MRI: in vivo characterization and first insights
Michal Rivlin, Or Perlman, Gil Navon · 2023
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Description
Michal Rivlin, Or Perlman, and Gil Navon characterize, in a 2023 study, a brain imaging method that tracks a common dietary supplement as a metabolic marker. The method is a form of MRI that reads chemical exchange signals. Earlier work had shown it can detect uptake of glucosamine, a safe supplement, in breast cancer, in mice and in people.
The team asked whether the same trick works in the brain, and how the signal behaves there. After the supplement was given into a vein in mice, brain signals rose clearly. The rise was strongest in the cortex, the hippocampus, and the thalamus, and it held steady for forty minutes. Chemical analysis of brain extracts confirmed that the supplement and its products had built up. Since the substance crosses the blood brain barrier, the authors propose the method as a marker for diagnosing and tracking brain disorders.
Catalog record
| CREATOR | Michal Rivlin, Or Perlman, Gil Navon |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |