Acute irradiation induces a senescence-like chromatin structure in mammalian oocytes
Claudia Baumann, Xiangyu Zhang, Muthugapatti K. Kandasamy, Xiaohan Mei, Shiyou Chen, Kayvan F. Tehrani, Luke J. Mortensen, Wendy Watford, Ashley Lall, Rabindranath De La Fuente · 2023
Read Acute irradiation induces a senescence-like chromatin structure in mammalian oocytes by Claudia Baumann, Xiangyu Zhang, Muthugapatti K. Kandasamy, Xiaohan Mei, Shiyou Chen, Kayvan F. Tehrani, Luke J. Mortensen, Wendy Watford, Ashley Lall, Rabindranath De La Fuente (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10716162.txt.
Description
Claudia Baumann and a team of co-authors showed how radiation reshapes the DNA pack in mammal egg cells. Their study, from twenty twenty-three, deals with oocyte chromatin. How the mid scale pack shifts with age is not known. In egg cells, repeat DNA packs into tight balls that merge into centers and cling to the nucleolus. The team used gene switches, RNA reads, and super sharp imaging to watch the pack after a sharp dose.
In quiet egg cells, the centers moved more after the dose. In active ones, the fibers spread open in a senescence like form. Genes for stress guard and DNA repair rose. Readers in cell aging get a view of how one hard hit mimics old age in the egg.
Catalog record
| CREATOR | Claudia Baumann, Xiangyu Zhang, Muthugapatti K. Kandasamy, Xiaohan Mei, Shiyou Chen, Kayvan F. Tehrani, Luke J. Mortensen, Wendy Watford, Ashley Lall, Rabindranath De La Fuente |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |