The role of HIF in angiogenesis, lymphangiogenesis, and tumor microenvironment in urological cancers
Shen Lin, Yueyang Chai, Xiangyi Zheng, Xin Xu · 2023
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Description
Shen Lin, Yueyang Chai, Xiangyi Zheng, and Xin Xu review how low oxygen inside tumors drives their growth in cancers of the urinary system, in a paper published in 2023. Solid tumors often outgrow their blood supply and turn hypoxic. A master switch protein that senses oxygen then rewires the tumor's behavior.
That switch pushes the tumor to grow new blood vessels and lymph channels, its routes for spread. It matters most in kidney, prostate, and bladder cancers, the review's focus. The same low-oxygen setting also draws in support cells that damp the immune attack, helping the tumor hide. The authors gather the mechanisms linking the oxygen switch to vessel growth and to the tumor's wider neighborhood. Their aim is a clear map for researchers hunting drug targets in these cancers.
Catalog record
| CREATOR | Shen Lin, Yueyang Chai, Xiangyi Zheng, Xin Xu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |