Analysis of vector genome integrations in multicentric lymphoma after AAV gene therapy in a severe hemophilia A dog
Lucas Van Gorder, Bhavya S Doshi, Elinor Willis, Timothy C Nichols, Emma Cook, John K Everett, Elizabeth P Merricks, Valder R Arruda, Frederic D Bushman, Mary Beth Callan, Benjamin J Samelson-Jones · 2023
Read Analysis of vector genome integrations in multicentric lymphoma after AAV gene therapy in a severe hemophilia A dog by Lucas Van Gorder, Bhavya S Doshi, Elinor Willis, Timothy C Nichols, Emma Cook, John K Everett, Elizabeth P Merricks, Valder R Arruda, Frederic D Bushman, Mary Beth Callan, Benjamin J Samelson-Jones (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10716008.txt.
Description
Adeno-associated viral (AAV) vectors have traditionally been viewed as predominantly nonintegrating, with limited concerns for oncogenesis. However, accumulating preclinical data have shown that AAV vectors integrate more often than previously appreciated, with the potential for genotoxicity. To understand the consequences of AAV vector integration, vigilance for rare genotoxic events after vector administration is essential.
Catalog record
| CREATOR | Lucas Van Gorder, Bhavya S Doshi, Elinor Willis, Timothy C Nichols, Emma Cook, John K Everett, Elizabeth P Merricks, Valder R Arruda, Frederic D Bushman, Mary Beth Callan, Benjamin J Samelson-Jones |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |