One-year efficacy and safety of naloxegol on symptoms and quality of life related to opioid-induced constipation in patients with cancer: KYONAL study
Manuel Cobo Dols, Carmen Beato Zambrano, Luis Cabezón-Gutiérrez, Rodolfo Chicas-Sett, María Isabel Blancas López-Barajas, Francisco Javier García Navalón, José Luis Fírvida Pérez, Gala Serrano Bermúdez, Pilar Togores Torres, Ignacio Delgado Mingorance, Alexandra Giraldo Marín, Anna Librán Oriol, Alf · 2023
Read One-year efficacy and safety of naloxegol on symptoms and quality of life related to opioid-induced constipation in patients with cancer: KYONAL study by Manuel Cobo Dols, Carmen Beato Zambrano, Luis Cabezón-Gutiérrez, Rodolfo Chicas-Sett, María Isabel Blancas López-Barajas, Francisco Javier García Navalón, José Luis Fírvida Pérez, Gala Serrano Bermúdez, Pilar Togores Torres, Ignacio Delgado Mingorance, Alexandra Giraldo Marín, Anna Librán Oriol, Alf (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10715504.txt.
Description
Manuel Cobo Dols and co-authors followed cancer patients for a year on a drug for constipation caused by strong painkillers, in a study published in 2023. Opioid pain drugs often slow the bowel, and standard laxatives may not suffice. The drug, naloxegol, blocks opioid effects in the gut while sparing pain relief. The team tracked 126 patients in everyday Spanish clinics, most of them men with an average age near sixty-two.
Symptom and life quality scores improved from the start and held through the year. By twelve months, about seventy-eight percent of patients counted as responders to the drug. Overall life quality stayed level rather than falling as illness advanced. Side effects appeared in about fifteen percent of patients, mostly gut complaints in the first two weeks, and most were mild. The authors call the drug a safe, lasting option for this group.
Catalog record
| CREATOR | Manuel Cobo Dols, Carmen Beato Zambrano, Luis Cabezón-Gutiérrez, Rodolfo Chicas-Sett, María Isabel Blancas López-Barajas, Francisco Javier García Navalón, José Luis Fírvida Pérez, Gala Serrano Bermúdez, Pilar Togores Torres, Ignacio Delgado Mingorance, Alexandra Giraldo Marín, Anna Librán Oriol, Alf |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |