Fatty Oil of Descurainia Sophia Nanoparticles Improve Monocrotaline-Induced Pulmonary Hypertension in Rats Through PLC/IP3R/Ca2+ Signaling Pathway
Yajuan Zheng, Peipei Yuan, Zhenkai Zhang, Yang Fu, Saifei Li, Yuan Ruan, Panying Li, Yi Chen, Weisheng Feng, Xiaoke Zheng · 2023
Read Fatty Oil of Descurainia Sophia Nanoparticles Improve Monocrotaline-Induced Pulmonary Hypertension in Rats Through PLC/IP3R/Ca2+ Signaling Pathway by Yajuan Zheng, Peipei Yuan, Zhenkai Zhang, Yang Fu, Saifei Li, Yuan Ruan, Panying Li, Yi Chen, Weisheng Feng, Xiaoke Zheng (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10714987.txt.
Description
Yajuan Zheng and nine co-authors tested a plant oil treatment in two thousand twenty-three for high blood pressure in the lungs of rats. The oil, from Descurainia sophia seeds, is unstable and dissolves poorly, which limits its effect. The team wrapped the oil in tiny carrier particles to fix those weak points.
In cells, the particles curbed harmful growth of artery muscle cells and protected their power units, by blocking a calcium signal pathway. In rats, the treatment lowered artery pressure and eased damage and swelling in heart and lung. The study points to a better way to deliver this plant oil as a drug.
Catalog record
| CREATOR | Yajuan Zheng, Peipei Yuan, Zhenkai Zhang, Yang Fu, Saifei Li, Yuan Ruan, Panying Li, Yi Chen, Weisheng Feng, Xiaoke Zheng |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |