Effects of Dual-Release Hydrocortisone on Bone Metabolism in Primary and Secondary Adrenal Insufficiency: A 6-Year Study
Valeria Hasenmajer, Davide Ferrari, Dario De Alcubierre, Valentina Sada, Giulia Puliani, Ilaria Bonaventura, Marianna Minnetti, Alessandra Tomaselli, Riccardo Pofi, Emilia Sbardella, Alessia Cozzolino, Daniele Gianfrilli, Andrea M Isidori · 2023
Read Effects of Dual-Release Hydrocortisone on Bone Metabolism in Primary and Secondary Adrenal Insufficiency: A 6-Year Study by Valeria Hasenmajer, Davide Ferrari, Dario De Alcubierre, Valentina Sada, Giulia Puliani, Ilaria Bonaventura, Marianna Minnetti, Alessandra Tomaselli, Riccardo Pofi, Emilia Sbardella, Alessia Cozzolino, Daniele Gianfrilli, Andrea M Isidori (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10714896.txt.
Description
Valeria Hasenmajer and co-authors track bone health over six years in patients whose adrenal glands fail, in a 2023 study. Such patients take daily steroid drugs to replace missing hormones, and high doses can thin bone. A dual release form of the drug aims to mimic the body's own daily rhythm more closely.
Thirty two patients switched from standard pills to the dual release form at matched doses. Bone density at hip and spine held steady over the follow up, and bone turnover markers stayed flat. A finer score of bone texture slipped a bit, more in women, which the team reads as age change rather than drug harm.
Catalog record
| CREATOR | Valeria Hasenmajer, Davide Ferrari, Dario De Alcubierre, Valentina Sada, Giulia Puliani, Ilaria Bonaventura, Marianna Minnetti, Alessandra Tomaselli, Riccardo Pofi, Emilia Sbardella, Alessia Cozzolino, Daniele Gianfrilli, Andrea M Isidori |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |