Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis
Lisia Barros Ferreira, Keryn A Williams, Giles Best, Cameron D Haydinger, Justine R Smith · 2023
Read Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis by Lisia Barros Ferreira, Keryn A Williams, Giles Best, Cameron D Haydinger, Justine R Smith (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10714664.txt.
Description
Lisia Barros Ferreira and co-authors review how swelling signals can break the blood barrier that guards the retina. Their 2023 paper focuses on non-infectious uveitis, a group of immune diseases that attack the eye. When the rear of the eye is involved, barrier breakdown can cost vision. The barrier rests on vessel lining cells, braced by helper cells around them. Six signals stand out across the literature as likely barrier breakers.
For each signal, the review lays out its normal role and the proof tying it to barrier harm. Proof comes from lab work, from fluids drawn from patient eyes, and from trials of drugs that block these signals. Gaps in knowledge are named as well. The authors argue that knowing which signal does what can steer drug choices. Better targeting may guard the rear of the eye and save sight.
Catalog record
| CREATOR | Lisia Barros Ferreira, Keryn A Williams, Giles Best, Cameron D Haydinger, Justine R Smith |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |