Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders
Junping Ye, Zhanwang Huang, Qiyang Li, Zhongwei Li, Yuting Lan, Zhongju Wang, Chaoying Ni, Xiaohui Wu, Tingyun Jiang, Yujing Li, Qiong Yang, Junghwa Lim, Cun-Yan Ren, Meijun Jiang, Shufen Li, Peng Jin, Jian-Huan Chen, Cunyou Zhao · 2023
Read Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders by Junping Ye, Zhanwang Huang, Qiyang Li, Zhongwei Li, Yuting Lan, Zhongju Wang, Chaoying Ni, Xiaohui Wu, Tingyun Jiang, Yujing Li, Qiong Yang, Junghwa Lim, Cun-Yan Ren, Meijun Jiang, Shufen Li, Peng Jin, Jian-Huan Chen, Cunyou Zhao (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10714646.txt.
Description
Junping Ye and a large team study identical twins who differ in mental illness in this two thousand twenty-three paper. One twin may develop schizophrenia or bipolar disorder while the other does not. Since the twins share their genes, such gaps hint at chemical marks on DNA. The mark in focus is a modified base called 5hmC, which helps control gene activity. The team asked whether this mark leans toward one copy of a gene.
They combined a method that labels the mark with full genome reads from blood. Samples came from twin pairs split by these disorders. Shifts in the mark at control regions tracked with the twins' differing traits. The study links epigenetic marks to genetic variants in a new way. It may help explain why identical genomes can yield unlike minds.
Catalog record
| CREATOR | Junping Ye, Zhanwang Huang, Qiyang Li, Zhongwei Li, Yuting Lan, Zhongju Wang, Chaoying Ni, Xiaohui Wu, Tingyun Jiang, Yujing Li, Qiong Yang, Junghwa Lim, Cun-Yan Ren, Meijun Jiang, Shufen Li, Peng Jin, Jian-Huan Chen, Cunyou Zhao |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |