Role of IL-33-ST2 pathway in regulating inflammation: current evidence and future perspectives
Yilu Zhou, Zhendong Xu, Zhiqiang Liu · 2023
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Description
A signal protein called IL-33 sits inside cell nuclei until damage or stress sets it free. It then wakes immune cells through a receptor known as ST2. Yilu Zhou, Zhendong Xu, and Zhiqiang Liu review in 2023 what this pathway does in inflamed lungs and beyond. Levels of both partners run high in chronic obstructive pulmonary disease, and smoke exposure can switch the pathway on. It drives type 2 inflammation and calls in chemical messengers.
The same pathway also helps clear bacteria and repair tissue, which makes it a double-edged target. The authors survey its roles in sepsis, asthma, and lung disease, then map drug targets along the pathway that future treatments might use.
Catalog record
| CREATOR | Yilu Zhou, Zhendong Xu, Zhiqiang Liu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |